Topics

Cannabis contains THC and CBD, acts on the endocannabinoid system, and may have relevant interactions with some antiretrovirals, especially protease and integrase inhibitors.

A practical guide to planning encounters with substances, reducing harm, and caring for the body before, during, and after.

Cocaine is a central nervous system stimulant that increases dopamine, noradrenaline, and serotonin. It carries important cardiovascular risks and may interact dangerously with erection medicines, antidepressants, and other stimulants.

Guide to community care and identity: building community, respect for diversity, collective consent, support networks, safe spaces, pride and identity, and activism.

PDE5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil) help erections by increasing blood flow; when combined with some medicines or substances they can cause serious effects.

Interaction table between feminising hormones (estradiol, spironolactone, progesterone, cyproterone acetate) and psychoactive substances, with risk levels.

Nine general harm reduction recommendations for people who use substances and/or take HIV treatment or HIV prevention medicines.

GHB and GBL are central nervous system depressants that act on GABA receptors. The margin between a recreational dose and an overdose is very narrow, especially when combined with alcohol, other depressants, or antiretrovirals that can increase their effects.

Interaction table between hepatitis B medicines (TDF, TAF, entecavir) and psychoactive substances. Table 02A.

Opioids act on the central nervous system, producing pain relief, relaxation, and euphoria. The main risk is respiratory depression and overdose, which gets worse with other depressants and some antiretrovirals. Naloxone can reverse an overdose.

Inhalants are chemical substances whose vapours are breathed in to produce a brief high and disinhibition. Repeated use may cause brain, heart, liver, and kidney damage. Relevant pharmacological interactions with modern antiretrovirals are not expected.

Ketamine is a dissociative anaesthetic that acts on NMDA receptors. It may interact with several antiretrovirals that change its levels, increasing the risk of deep sedation or reduced effectiveness.

LSD is a psychedelic that alters perception and consciousness for 8 to 12 hours. Relevant pharmacological interactions with modern antiretrovirals are not expected, although emotional and environmental context strongly shape the experience.

MDMA is a stimulant and empathogen that increases serotonin, dopamine, and noradrenaline. It may have important interactions with protease inhibitors and some integrase inhibitors, increasing the risk of hyperthermia and cardiovascular toxicity.

Methamphetamine is a central nervous system stimulant with effects that may last 6 to 24 hours or longer. It may reduce ART adherence and has relevant interactions with antidepressants and erection medicines. The risks of psychosis, sleep deprivation, and redosing are especially important in chemsex contexts.

General interaction table between the feminising and masculinising hormones most commonly used by trans people and psychoactive substances, with risk levels.

Interaction table between masculinising hormones (testosterone in different formulations) and psychoactive substances, with risk levels and recommendations.

PEP is an emergency treatment that reduces HIV risk after a possible exposure; it should be started within 72 hours and taken for 28 days without interruption.

Poppers are inhaled alkyl nitrites that produce brief euphoria, muscle relaxation, and vasodilation. They are frequently used in sexual contexts.

PrEP is a highly effective medicine (>99%) that reduces the risk of acquiring HIV in HIV-negative people; daily, 2-1-1, and injectable regimens are available.

Guide to sexual practices involving power dynamics and emotional care (D/s, Master/Slave, Humiliation, Degradee, Primal, Age Play, Brat), with emphasis on consent, communication, and aftercare.

Guide to sexual practices involving power dynamics and emotional bonds (D/s, Master/Slave, Humiliation, Degradee, Primal, Age Play, Brat), with levels of care and harm reduction strategies.

Guide to financial care in relationships and sexual practices: clear agreements, financial boundaries, conscious payment, financial autonomy, and prevention of economic exploitation.

Guide to sexual practices with physical and body care (bondage, spanking, electro, wax, breath play) and erotic and sensory exploration, with care levels and harm reduction strategies.

Guide to sexual practices (vaginal sex, anal sex, oral sex, frottage, group or shared sex, fluid exchange, and sex toys) with levels of care, risks, and harm reduction strategies.

Detailed interaction table between trans hormones (estrogens, antiandrogens, progestogens, testosterone) and psychoactive substances, including mechanisms and risk levels.